科研項(xiàng)目: 1.首都醫(yī)科大學(xué)科研培育基金,PYZ22142,GBP5影響TCA代謝酶琥珀酰化修飾促進(jìn)結(jié)核感染巨噬細(xì)胞代謝重塑和免疫應(yīng)答研究,2023-01-01至2023-12-31,5萬,主持 2.中科院病原微生物與免疫學(xué)重點(diǎn)實(shí)驗(yàn)室,面上項(xiàng)目,CASPMI202201,GBP5 促進(jìn)結(jié)核感染巨噬細(xì)胞中 NLRP3 炎癥小體活化的機(jī)制研究,2022-07-01至2024-07-31,在研,主持 3.國家自然科學(xué)基金委員會(huì), 青年科學(xué)基金項(xiàng)目, 81701971, GBP5在抗結(jié)核感染中對巨噬細(xì)胞炎癥小體調(diào)控的機(jī)制研究,2018-01-01 至 2020-12-31,結(jié)題,主持 4.中華人民共和國科學(xué)技術(shù)部, 艾滋病和病毒性肝炎等重大傳染病防治科技部重大專項(xiàng)子任務(wù), 2018ZX10101004002, 多種族兒童結(jié)核病生物樣本庫的建立與診療技術(shù)驗(yàn)證和示范推廣, 2018-01 至 2021-06,結(jié)題,主持 5.北京市衛(wèi)生健康委員會(huì), 首都衛(wèi)生發(fā)展科研專項(xiàng)青年優(yōu)才項(xiàng)目, 2018-4-1142, 第三代頭孢菌素在新生兒抗感染治療中的群體藥代動(dòng)力學(xué)研究, 2018-01 至 2021-12, 結(jié)題,主持 6.國家外專局,出國培訓(xùn)項(xiàng)目, P182001033, GBP5基因?qū)τ诮Y(jié)核分枝桿菌感染后巨噬細(xì)胞功能以及能量代謝的影響, 2018-11 至 2019-05,結(jié)題,主持 7. 國家自然科學(xué)基金委員會(huì), 應(yīng)急管理項(xiàng)目,81441067,基于藥物基因組學(xué)的兒童抗結(jié)核藥物致肝毒性DNA標(biāo)記物的篩選及預(yù)測,2015-01-01至2015-12-31,結(jié)題,主持 8.中國博士后基金委員會(huì),面上項(xiàng)目,188384,巨噬細(xì)胞凋亡相關(guān)基因多態(tài)性與結(jié)核病易感相關(guān)性研究,2013-07至2014-12,結(jié)題,主持 9.北京市人力資源和社會(huì)保障局,人才培養(yǎng),2013ZZ,細(xì)胞因子、細(xì)胞因子受體以及相關(guān)信號(hào)通路分子基因多態(tài)性與中國兒童結(jié)核病易感的相關(guān)性研究,2013-05至2014-07結(jié)題,主持 代表性論文: (1) Xue Tian#, Lei Dong#, Ting-Ting Jiang#, Bo-Hao Tang, Ze-Ming Wang, Yue-E Wu, Dian-Ping You, Jing Bi, Su-Yun Qian*, Hui Qi*; Adong Shen* Meropenem for children with severe pneumonia: Protocol for a randomized controlled trial, Frontiers in Pharmacology, 2022;13:1021661. (2) Hui Qi; Yuee Wu; Yali Liu; Chen Kou; Zeming Wang; Xiaoxia Peng; Liang Chen; Hong Cui; Yajuan Wang; Jieqiong Li; Wei Zhao; Adong Shen*; Latamoxef for Neonates With Early-Onset Neonatal Sepsis: A Study Protocol for a Randomized Controlled Trial, Frontiers in Pharmacology, 2021, 12. (3) Xue Li#, Hui Qi#, Fei Jin#, Bufan Yao, Yuee Wu, YuJie Qi, Chen Kou, Xirong Wu, Xiaojing Luo, Yanhua Shen, Xu Zheng, Yonghong Wang, Fang Xu, Weiwei Jiao, Jieqiong Li, Jing Xiao, Yining Dong, Bin Du, Haiyan Shi, Baoping Xu, Adong Shen*, Wei Zhao*; Population Pharmacokinetics-Pharmacodynamics of Ceftazidime in Neonates and Young Infants: Dosing Optimization for Neonatal Sepsis, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2021,02: 105868. (4) Xu Fang; Qi Hui; Li Jieqiong; Sun Lin; Gong Juanjuan; Chen Yuanying; Shen Adong; Li Wei ; Mycobacterium tuberculosis infection up-regulates MFN2 expression to promote NLRP3 inflammasome f ormation, The Journal of Biological Chemistry, 2020, 295(51): 17684-17697. (5) Hui Qi#; Chen Kou#; YuJie Qi#; BoHao Tang; YueE Wu; Fei Jin; Xiaojing Luo; Yanhua Shen; Yajie Guo; Xue Qi; Yacui Wang; Qian Dong; Xingkai Chen; Haiyan Shi; Yi Zheng; Wei Zhao*; Adong Shen*; Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants, International Journal of Antimicrobial Agents. 2019, 53(3): 347-351. (6) Hui Qi#; Yongbiao Zhang#; Lin Sun#; Cheng Chen#; Biao Xu; Fang Xu; Jiawen Liu; Jincheng Liu; Chen Chen; Weiwei Jiao; Chen Shen; Jing Xiao; Jieqiong Li; Yajie Guo; Yonghong Wang; Qinjing Li; Qingqin Yin; Yingjia Li; Ting Wang; Xingyun Wang; Mingliang Gu; Jun Yu And Adong Shen*; Discovery of susceptibility loci associated with tuberculosis in Han Chinese, Human Molecular Genetics, 2017, 26(23): 4752-4763. 3. 獲獎(jiǎng): (1) 結(jié)核病診斷新技術(shù)的建立及推廣應(yīng)用,北京醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng),2022年,第五完成人; (2) 結(jié)核病關(guān)鍵診療技術(shù)的建立及推廣應(yīng)用,中華醫(yī)學(xué)科技獎(jiǎng)三等獎(jiǎng),2022年,第六完成人; (3) 結(jié)核病關(guān)鍵診斷技術(shù)的創(chuàng)新性建立及應(yīng)用,北京市科學(xué)技術(shù)獎(jiǎng)科學(xué)自然科學(xué)獎(jiǎng), 2022年,第七完成人。 |